Nationwide Shortage of Tuberculin Skin Test Antigen APLISOL®

The manufacturer of APLISOL® has notified the CDC of a nationwide shortage of the TB skin test antigen. The shortage began in June 2019 and is expected to last three to ten months. TUBERSOL® is still available at this time and is a FDA approved TB skin test antigen. Providers should continue to follow state and federal regulations regarding TB skin testing for staff and residents until further notice. They should reach out to their local public health departments or the Missouri Department of Health and Senior Services (DHSS) Bureau of Communicable Disease Control and Prevention at 573-751-6113 with any questions or problems obtaining the antigen.

Please see the CDC Health Advisory for more information at